Tighina Fortress, located on the bank of the Dinester River was one of the most powerful fortresses of Moldova. During the '70-'80s of the 16th century, Tighina was incorporated to the Principality of Moldova. Tighina becomes an important point on the Moldovan Trade Route linking Western Europe with Orient through the Danube ford from Isaccea, Byzantine regions from the right of the Danube with Caffa, Genoese colony in the Crimea.